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Created with Fabric.js 1.4.5 Loss of territories - productive land,industries and raw resources Plasmonic Label free, Real time detection Surface plasmons resonance (SPR) biosensors technology it describes how the electromagnetic (EM) field can be confined over a dimension of the order or smaller than the wavelength. Enhanced optical near field is achieved when the EM field interacts with the conductive electrons at the metal interface or in metallic nanostructures. metallic nanoparticles metallic nanoparticles Plasmonic biosensors Surface enhanced Raman scattering (SERS) Surface enhanced fluorescence (SEF) Very sensitive to changes in the effective refractive index of the surrounding medium. Selective binding of the biomarker produce a shifting of the SP resonance. SPR can provide affinity and kinetic data from proteinpeptide interaction analysis to cellular ligation experiments. Sensitivity around nM range. Plasmonics metallic surfaces Enhancement of the localized SPR fields lead to an increase in the emission and scattering signals of molecules by severalorders of magnitude. Incident light can be coupled with the metal interface at angles greater than thecritical angle. The reflected light exhibits a sharp attenuation (SPR minimum)in reflectivity owing to the resonant transfer of energy from the incident light to a surface plasmon. The incident angle (or wavelength) at which the resonance occurs is highly dependent upon the refractive index in the immediate vicinity ofthe metal surface. Localized Surface plasmons resonance (LSPR) Future, plasmonic-fluidic integrated sensors References[1] Alexandre G. Brolo, Plasmonics for future Biosensors, Nature Photonics, 709, 6, 2012.[2] P. Zijlstra, P. M. R. Paulo, M. Orrit, Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod, Nature nanotechnology ,304,7,2012.[3] A. Abbas, M. J. Linman, Q. Cheng. New trends in instrumental design for surface plasmon resonance-based biosensors, Biosensors and Bioelectronics, 26,1815, 2011. SPR and LSPR Comparison Future biosensors will be able to quantify several species of interest(multiplex detection) by using the advances in microelectromechanicalsystems (MEMS), fluid manipulation in micrometre-sized channels,automated chemical and biochemical operations (lab-on-a-chip), andoptofluidics integration. Single-molecule sensitivity can be achieved Surface plasmons polaritons (SPP) are traveling charge density waves at the surface of conducting materials (which serves as a waveguide). Surface plasmons resonance (SPR) is a collective oscillation of these free charges (conduction electrons) present at the interface of two media (metaldielectric) with permittivities of opposite sign. Localized surface plasmons (LSPs) are associated with electron plasma density oscillations on metallic nanoparticles ( e.g. 10 nm). Colour gradient shows the field intensity distribution The enhanced field at the surface (red) decreases towards the dielectric medium (blue) Smaller propagation length valuesHigher sensitivity
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