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Created with Fabric.js 1.4.5 MEDROL(METHYLPREDNISOLONE) -Tablet;oral (PO) Julian Rosales- Gonzales p.5 -4mg -Steroid anti-inflammatory-Controls or prevents inflammationby controlling rate of protein synthesis,suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level Mechanism of action Common dosage Absorption- Onset: 1-2 hr (PO); 4-8 days(IM); 1 week (intra-articular) Duration: 30-36 hr (PO); 1-4 weeks (IM) Peak plasma time: 31 min (IV) Distribution- Vd: 0.7-1.5 L/kgMetabolism- Extensively metabolized in liverExcretion- Half-life: 3-3.5 hr; Dialyzable: Hemodialysis, slightly; Total body clearance: 16-21 L/hr; Excretion: Urine (mainly, as metabolites), feces (minimally) -The purpose of this study is to attenuate the systemic inflammatory response after Endovascular repair of abdominal aortic aneurysms, by administration of a single preoperative dosage of Methylprednisolone.Condition- Abdominal Aortic Aneurysms Pharmacokinetics Clinical study Route of administration -Generic= $.75-Name brand= $1.15 Price-4mg -Untreated serious infections-Documented hypersensitivity-Traumatic brain injury (high doses) Contraindications - Endocrine Disorders -Hypercalcemia associated with cancer-Rheumatic Disorders -Ankylosing spondylitis- Neoplastic disease -Acute leukemia of childhood Indications Geriatrics Pregnant Women Nursing Women Warnings and precautions -Corticosteroids may mask some signs of infection, and new infections may appear during their use. Pediatrics
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