Infographic Template Galleries

Created with Fabric.js 1.4.5 JANUVIA Sitagliptin Bioavailability: 87%Peak Plasma Time - 1-4 hr Karina ChowdhuryGonzalez, p.1 The body makes a natural hormone called incretin, which notifies the body to release insulin after consuming food. Insulin is a hormone produced by beta cells in the pancreas that lowersblood sugar. It also decreases sugar production in the liver. Some people who have type 2 diabetes do not produce an adequate amount of incretin. DPP-4 inhibitors are helpful, because they help the body keep incretin longer, which prompts insulin to be released,by this means lowering blood sugar. Pharmacokinetics Pharmacokinetics Half life: 12.4 hrUrine (87%), feces (13%) Take with or without foodSwallow tablet wholeDo not chew, crush, or spit Route of adminstration ABSORPTION DISTRIBUTION Protein Bound: 38%Vd: 198 mL METABOLISM Limited primary viaCYP3A4 and CYP2C8 EXCRETION 100 mg PO qday Common Dosage Comes in tablets50 mg100 mg200 mg Mechanization of Acton -Patients with type 2 diabetes mellitus Special populations Warnings/precautions Cost: $323.92 for 30 100 mg tablets Januvia controls high blood sugar in patients with type 2 diabetesand is used with an appropriate diet and exercise regimen. Control-ling blood sugar is important in preventing blindness, nerve problems,kidney damage, loss of limbs, and sexual function problems. Patientshave a smaller risk of heart attack or stroke if diabetes is properlycontrolled. Indications/usage Stop taking Januvia if any of these side effects occur: signs of pancreatitis (persistent nausea/vomiting, loss of appetite, severestomach/abdominal/back pain). Side Effects Contraindications Documented hypersensitivity -Use carefully with renal/hepatic impairment, or heart failure-Diabetic ketoacidosis patients should not use-Type 1 diabetes mellitus - not effective-Can cause acute pancreatitis -Before using tell doctor any medical history of: kidney disease, pancreatitis, and gallstones.-Patients may experience blurred vision, dizziness, or drowsiness -Drinking alcohol may increase risk of low blood sugar.-Diabetes may be worsened with pregnancy -Not known if drug passes into breast milk. 2 studies look upon risk of heart failure with DPP-4 inhibitors1. Pts with type 2 diabetes who received prescription for metformin and DPP-4 inhibitor had small, increased risk for congestive heart failure compared to pts who received metformin and other oral antidiabetic agents.2. DPP-4inhibitors were not associated with increased risk of heart disease, compared with nonDPP-4 inhibitors. Clinical studies
Create Your Free Infographic!