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Created with Fabric.js 1.4.5 start from scratch[clears the canvas] Severe Combined Immunodeficiency What is this? Severe Combined Immunodeficiency or S.C.I is a born illness where the child is born without a working immune system leaving the childvulnerable to all illnesses which would killhim/her. How do you obtain this before birth? This illness is contracted when one of your two parents who carries this gene for the illness most likely being your mother instead of your father unless your father hadit and was effected by it. (shown in the chart above) Severe combined Immunodeficiency-Meaning SCID is the result of an immune system so highly compromised that it is considered almost absent. SCID patients are usually affected by severe bacterial, viral, or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea, and failure to thrive. How to treat this disorder or disease! If your childs doctor suspects that he/she may have SCID, they will initially use antibiotic, antifungal, and antiviral medications to treat any active infections that your child may have. They will also start antibiotics and Intravenous Immune Globulin (IVIG) to try and protect your child from getting some of the infections that they are susceptible to. Sources! Fun Facts! - The chance in being born with SCID is insanely low so no worries for many people- If you are born with the disease and are showing symptoms immediately contact your doctor so you can be treated immediately and pull through safely- There are a variety of treatments for SCID so you choose the one you are most comfortable with Whats my chance in getting this?! The chance in being born with this disease is very low but its always safe to go to your doctor and check to make sure you're not at risk What causes SCID? There are several types of SCID. The most common form is caused by a mutation in the SCIDX1 gene located on the X chromosome. This gene encodes a protein that is used to build a receptor called IL2RG (interleukin-2 receptor). These receptors sit in the plasma membrane of immune cells. The receptors' job is to allow two types of immune cellsT cells and B cellsto communicate. When the gene is mutated, the receptors cannot form and are absent from immune cells. As a result, the immune cells can't communicate with one another about invaders. Too few T and B cells are made to fight off the infection, and the body is left defenseless. Bubble boy of 1984
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