Infographic Template Galleries

Created with Fabric.js 1.4.5 Enzyme Inhibition Reversible Inhibitors Sources:http://www.chemistry.wustl.edu/~edudev/LabTutorials/HIV/DrugStrategies.htmlhttp://www.ucl.ac.uk/~ucbcdab/enzass/inhibition.htm#uncomphttp://www.kscience.co.uk/as/module1/inhibitors.htmhttp://www.elmhurst.edu/~chm/vchembook/671antidepress.html Binds to substrate-enzymecomplex, only thatundergoes reactionto form product slowly. Reacts with the enzyme substratecomplex and slows the rate of reaction to form a product. A molecule binds to an enzyme and decreases its activity. Competes with the substrate for the active site. Competitive Noncompetitive Uncompetitive FACTS about Enzyme Inhibition: >Can be reversible or irreversible.>Reduce enzyme activity.>Reversible inhibition can regulate metabolic pathways ex. Acetyl COA>Can be produced naturally by the body to regulate blood pressure ex. ACE inhibitors -Angiotensin II>Enzyme inhibitors are now mainly used in Prescription Drugs we use.Examples of enzyme inhibitors in Drugs:Protease inhibitors - inhibit proteolysis/ protein cleavageReverse Transcriptase inhibitors (AZT) - inhibit synthesis of viral DNA from mRNASelective Serotonin Re-uptake Inhibitors -CNS Antidepressants -ex.Prozac, ClomiprimineMonoamine Oxidase Inhibitors (MAOIs) -prevent breakdown or inactivation of norepinephrine -ex.phenelzine Kinetic Effect on inhibited Reaction Type of inhibition....Km.....Vmax.....Km/Vmax Competitive............high....same.....increase Non-Competitve......same...lower.....increase Uncompetitive........lower...lower......Same
Create Your Free Infographic!