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Created with Fabric.js 1.4.5 Enzyme Inhibition 2005 2006 2007 2008 2009 2010 2011 2012 JACK Reversible Inhibitors SF equation JOSH Super Friend extra travel bond Sources: vailpartybond Binds to substrate-enzymecomplex, only thatundergoes reactionto form product slowly. Six Atom Molecule Reacts with the enzyme substratecomplex and slows the rate of reaction to form a product. A molecule binds to an enzyme and decreases its activity. Competes with the substrate for the active site. Atom adds drawing, drinkingparting skills Competitive Noncompetitive Uncompetitive FACTS about Enzyme Inhibition: >Can be reversible or irreversible.>Reduce enzyme activity.>Reversible inhibition can regulate metabolic pathways ex. Acetyl COA>Can be produced naturally by the body to regulate blood pressure ex. ACE inhibitors -Angiotensin II>Enzyme inhibitors are now mainly used in Prescription Drugs we use.Examples of enzyme inhibitors in Drugs:Protease inhibitors - inhibit proteolysis/ protein cleavageReverse Transcriptase inhibitors (AZT) - inhibit synthesis of viral DNA from mRNASelective Serotonin Re-uptake Inhibitors -CNS Antidepressants -ex.Prozac, ClomiprimineMonoamine Oxidase Inhibitors (MAOIs) -prevent breakdown or inactivation of norepinephrine-ex.phenelzine Non-competitive
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