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Created with Fabric.js 1.4.5 United States 14% 20% 16% north west north east south east west coast represented Warnings Contraindications Common Dosage Absorption Distribution - Hypothyroidism- Hepatic or renal impairment- Should use caution when pregnant or nursing- Should use cation in geriatric and debilitated patients Hydrocodone:- Takes about 3.8 hrs for half it to be eliminatedAcetaminophen:- Takes 1.25-3 hrs for half of it to be eliminated from the body - MAO Inhibitors- Other opioids and opiates - Regular- ES (Extra Strength)- HP (High Potency) Different Kinds of Vicodin Regular:- 1-2 every 4-6 hours- Should not exceed 8 tablets per dayES and HP:- 1 every 4-6 hours- Should not exceed 6 tablets per day Elimination Hydrocodone + Acetaminophen Mechanism of Action - Take about 1.3 hours to be fully absorbed into the bloodstream- Average concentration is 23.6 ng/mL at 1.3 hours Hydrocodone:- O-demethylation- N-demethylation- 6-keto reductionAcetominaphen- Liver (conjugation) Hydrocodone:- delta-receptor in the limbic region- kappa-receptor in modulating regions- mu-receptor in cerebral cortexAcetaminophen:- inhibits synthesis of prostaglandins Vicodin Metabolism To whom is Vicodin prescribed? By Maheep Myneni - Prescribed after certain surgical procedures- Sometimes prescribed for long-term pain Clinical Studies - Bloodstream- Breastmilk - Vicodin as been proven to help with chronic lower back pain- Significantly lowered lower back pain versus placebo- Proven to be effective even when used at half the typicaldosing period
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