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Created with Fabric.js 1.4.5 Generic: Montelukast Singulair Clinical Studies Cost Contraindications Singulair is a leukotriene inhibitor, leukotrienes are chemicals your body releases when you breathe in an allergen. They cause your lungs to swell and yourairway muscles to tighten, resulting in asthma symptoms. TESTING To get feedback from users Exercise- Induced Bronchoconstriction (EIB): Used to brevent exercise- induced bronchoconstriction for patients 6 years and up. Indications/Usage Mechanism of Action 5 participants Distribution: The steady state volume of distribution averages 8-11 liter and more than 99% is bound to plasma cells USABILITY Special Populations INQUIRY Neuropsychiatric events have been reported from all age groups. If this happens alert your prescriber, Singulair has not been proven to help with known Aspirin sensitivity. Avoidance of Aspirin should be continued. Renal Insufficiency: No dosage or adjustment needs to be recommended.since pharmacokinetics is not evaluated for patients with renal insufficiency. INSPECTION Metabolism: Extensively metabolized. In Vitro studies show that CYP3A4, 2C8, and 2C9 are involved in the metabolism of montelukast. 2C8 plays a major role. Excretion: Excreted mostly through the bile. May also be recovered in fecal material and urine. You should not use Singulair/ Montelukast if you have an hypersensitivity to any components of the medicine. Asthma: Used for prophylaxis and chronic tx of asthma in adults and pts 12 months and older. Hepatic Insufficiency: Decreased metabolism of montelukast with a 41% higher mean montelukast AUC after a single 10 mg dose. Gender: No difference in medication for females and males. More a DISCOVERY process than a EVALUATIVE process Common Dosage Administrated orally once a day15 years+ & Adults: one 10-mg tabletPediatric 6-14 years: one 5-mg chewable tablet Pediatric 2-5 years: one 4-mg chewable tablet or oral granulesPediatric: 12-23 months: one packet 4-mg oral granules Pharmacokinetics Absorption: (Fasted) 10-mg tablet adult mean peak (Cmax) montelukast concentration achieved in 3-4 hours.5 mg Cmax achieved in 2-2,5 hours.4mg Cmax in 2 hours for 2-5 yrs old.bioavailability: fasted- 73%With morning meal- 63% Warnings/ Precautions Singulair shouldn't besubstituted for inhaledor oralcorticosteroids. Acute Asthma- Singulair is not indicated to reverse bronchospasms during asthma attacks. A short-acting inhaled β-agonist would be needed in this case. Controlled clinical trials have been performed to observe the most common adverse reactions.Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis, and otitis were the most common reactions in descending order. 4 mg granule- $202.55 for 30 granules10 mg tablet- $202.55 for 30 tablets4 mg chewable tablet- $202.55 for 30 chewable tablets5 mg chewable tablet- $202.55 for 30 chewable tablets Allergic Rhinitis: Seasonal allergic rhinitis for 2 years and up and perennial allergic rhinitis for patients 6 months and older. Daniela Torres
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