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Created with Fabric.js 1.4.5 Route ofAdministration Route ofAdministration Loss of territories - productive land,industries and raw resources CommonDosages Vasotec(Enalapril Maleate) Oral tablet, intravenous solution,compounding powder, oral powder for reconstitution 2.5 mg - 20 mg 2x a day Max - 40 mg/ day Vasotec hydrolysis into enalprilat, which inhibits angiotension-converting enzymes in subjects. Pharmacokinetics Absorption:60% absorbency of enalapril within 1 hour; enalaprilat 3 to 4 hours Distribution: enalapril travelsacross the bloodbrain barrier, whereas enalaprilat does not. Metabolism: enalarpril, a prodrug, hydrolysis to enalaprilat. Excretion: 40% of enalaprilatis eliminated through the urine. About 94% recovered in excretion of urine and stool. Special Populations: Impaired Renal Function: Subjects with a glomerular filtration rate (GFR) of at least 30 mL/ min, enalaprilat levels increase and the steady state time is setbackChildren: The pharmacokinetics is the same as with adults. Clinical Studies Subjects who took enalapril showed signs of reduced blood presure levels in supineand standing positions. Subjects also showed resulted in the highest blood pressured decrease4 to 6 hours after taking a single dose. Indications/ Usage Vasotec treats hypertension, symptomatic congestive heart failure usually with diuretics and digitalis, left ventricular dysfunction, and renal impairment function. Contraindictions angioedema from a previous treatment,idiopathic or hereditary angioedema Mechanism ofAction Warnings/ Precautions Because ACE inhibitors affects the metabolism angioedema can occur. Subjects who have obstruction in the left ventricle and can cause changes in renal function, therefore must be careful. Cost Vasotec: 2.5mg for $10.57/ 30 tab5mg for $8.53/ 10 tab10mg for $10.82/ 10 tab 20 mg for $10.60/ 30 tab Enalapril:2.5mg for $280.73/ 30 tab 5mg for $324.95/ 30 tab10mg for $356.89/ 30 tab 20mg for $506.10/ 30 tab
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