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Created with Fabric.js 1.4.5 ProtonixPantoprazole ProtonixPantoprazole Dosage: Adults: Erosive Esophagitis GERD: 40 mg PO qDay for 8-16 wks 40 mg IV qDay for 7-10 days Zollinger-Ellison Syndrom: 40 mg PO qDay; up to 240 mg/day 80 mg IV q8-12hr up to 7 days Pediatrics: Erosive Esophagitis GERD: >5 years 15 kg to <40 kg: 20 mg PO qDay for up to 8 wks 40 kg or greater: 40 mg PO qDay for up to 8wks Mechanism of action: -prazole: Anti-ulcer, Proton Pump Inhibitor Decreases the amount of acid produced in the stomach Katalina LopezGonzalez, p.5 Bioavailability: 77% Onset: a 24 hr initial response Peak Plasma Time: 2.8 hr PO and at the end of an IV infusion Absorption: Distribution: Mainly to extracellular fluid Protein Binding is approx 98, primarily to albumin Vd (Volume Distribution): 11-23.6 L It is mainly metabolized in the liver through demethylation by CYP2C19 and oxidation by CYP3A4Slow metabolism in 3% of Caucasians and African Americans and 17-23% of Asian pts. Metabolism: Excretion: Urine: 71% Feces: 18% Half-life is 1hr and 3.5-10 hr in slow metabolizers Contraindications: hypersensitivity to pantoprazole or other PPIs ampicillin (Principen, Unasyn); a blood thinner such as warfarin (Coumadin, Jantoven); digoxin (Lanoxin, Lanoxicaps); a diuretic (water pill); ketoconazole (Nizoral); iron (Feosol, Mol-Iron, Fergon, Femiron, others); or methotrexate (Rheumatrex, Trexall). Precautions:Associated with increased incidence of Clostridium difficile associated with diarrhea (CDAD)Severe hepatic impairmentDecreased gastric acidity increases serum chromogranin A (CgA) levels and may cause false-positive dx results for neuroendocrine tumorsdrug should be temporarily discontinued to test CgA levelsGastric atrophy has been reported with long term use of PPIs
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