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Created with Fabric.js 1.4.5 Plavix works by preventing a natural substance called adenosine diphosphate (ADP) from binding to its receptors on platelets. ADP is one of the chemicals in the body that cause platelets to clump together and start the process of blood clotting. Clopidogrel Plavix and the main circulating metabolic bind reversibly to human plasma proteins. The bind is non-saturable up to a concentration of 100 μg/mL. Excertion Warnings/Precautions Contraindications Administrations After a single and repeated oral dosage of 75mg per day, Plavix rapidly absorbs. It is at least 50% on urinary flow of Plavix metabolites. Metabolism Around 50% of total radioactivity was excreted in urine and around 46% in feces over 5 days post-dosing. After a single, oral dose of 75 mg, plavix has a half-life of approximately 6 hours. The half-life of the active metabolite is about 30 minutes. Indications and Usage for Plavix Used for people with Acute Coronary Syndrome (ACS), including people who need to be managed medically and also managed with coronary revascularization. And for people with ST-elevation myocardial infarction (STEMI), Neonates and Infants up to 2 years: 0.2 mg/kg once dailyAdult : 75 mg orally once a day with or without foodChildren over 2 years of age: Optimal dose is not established; Initial dose: 1 mg/kg once daily; Absorption Oral: tablet 75 and 300 mg. Containing core of: Mannitol, Microcrystalline cellulose, Polyethelene glycol 6000, Low-substituted hydroxypropyl-cellulose, Hydrogenated castor oil double click to change this title text! Plavix Distribution Plavix goes to the liver to an unknown pharmacodynamically active chemical moiety, and then it metabolizes it. The two main metabolic pathways are; esterase's, leading to hydrolysis into an inactive carboxylic acid derivative, and the other mediate by many cytochromes P450. HypersensitivityActive bleedingSignificant liver impairment or cholestatic jaundice Shebly Sarrami Mechanism of action Pharmacokinetics Diminished Antiplatelet Activity Due to Impaired CYP2C19 Function:General Risk of Bleeding:Discontinuation of Plavix: May increase risk of cardiovascular eventsPatients with Recent Transient Ischemic Attack (TIA) or Stroke: Do not take with aspirin, shown to increase bleedingThrombotic Thrombocytopenic Purpura (TTP): Has been reported after using PlavixCross-Reactivity among Thienopyridines: reported that rashes, angioedema, and hematologic reaction are shown when taking Plavix Common Dosage Cost A month's supply of 75 milligram dose varied from less than $15 at several Costco pharmacies to $175 Clinical Studies Acute Coronary Syndrome: Adults were randomized to receive Plavix and showed better results in the first two months than the group with the placebo that stayed constant throughout the trail (12 months) Special Populations Renal Function ImpairmentHepatic Function-ImpairmentElderlyGender
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