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Created with Fabric.js 1.4.5 Percocet Oxycodone Hydrochloride & Acetaminophen Common Dosage Percocet 2.5 mg/325 mgPercocet 5 mg/325 mgPercocet 7.5 mg/325 mgPercocet 10 mg/325 mg OxycodoneHalf-life: 3.5 hrExcretion: Primarily in urine (8-14% as free oxycodone) AcetaminophenHalf-life: 2-4 hrExcretion: 90-100% in urine (principally as acetaminophen glucuronide with acetaminophen sulfate/mercaptate) Elimination Absorption & Distribution Bioavailability: Oxycodone (87%) acetaminophen (100%) Onset: Oxycodone (10-15 min) Duration: Oxycodone (3-6 hr) Peak plasma time: Oxycodone (0.5-1 hr) Special Population for pts with acute painthat requires the use ofopoids to treat Metabolism Oxycodone:hepatic P450 enzyme CYP2D6 and CYP3A4Acetaminophen:microsomal enzyme systems80-85% conjugated with glucuronic acid, sulfuric acid and cysteine Contraindications double click to change this header text! Hypersensitivityparalytic ileusbronchial asthma hypercarbiaSignificant respiratory depression Indications relief of moderate tomoderately severe pain. Warnings caution with head injury and increased intracranial pressure, severe hepatic/renal impairment, hypothyroidism, and Addison's disease Cost $275 for 30 tablets of Percocet 5mg/325mg Clinical Studies Reported to have causedrenal failure, mentalchanges, dysphonia, constipation, delusions,hypertension, and death
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