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Created with Fabric.js 1.4.5 Congestive Heart Failure Dermatalogic Reactions Edema Fatigue Headache Nausea Palpitations Peripheral Edema Somnolence Pruritus This is a calcium channel blocker thatobstructs calcium channels in blood vessels and myocardial cells, relaxing heart activity and muscle contraction so blood can flow more easily. Bioavailability: 64-90%Duration: 24 hrOnset: 24-96 hrPeak plasma time: 6-12 hr Absorption: Pharmacokinetics: Distribution: Protein bound: 93-98%Vd: 21 L/kg Common Dosage: Half-life: 30-50 hrExcretion: Urine (70%) Special Populations: Mechanism of Action: Warnings/Precautions: 5 mg/day Cost: Indications/Usage: Route of Administration: Adult and Geriatric: Hypertension, Coronary Artery Disease, AnginaPediatric: HypertensionPregnancy Category: CNursing Mothers: Not Suggested Angina HypertensionCoronary Artery Disease Metabolism: Contraindications: Contraindicated if patient is hyper-sensitive to Amlodipine.If coadministered with Dantrolene, toxicity increases and there is a rare incidence of hyperkalemia and cardiovascular collapse. Excretion: Amlodipine (Norvasc) Clinical Studies: By Mouth 268 pediatric hypertensive patients were randomized to Amlodipine 2.5 or 5 mg/day for 4 weeks and then again to the same dose or to placebo for 4 weeks. Patients receiving Amlodipine at the end of 8 weeks had much lower blood pressure than those receiving placebo. 2.5 mg30 tablets$6.77-$12.05 Metabolites: Pyridine analogueExtensively metabolized in liver Natalia SalazarGonzalez, p.5
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