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Created with Fabric.js 1.4.5 Malignant Hyperthermia Occurs in Anesthetic applications in adults Occurs in Anesthetic applications in children Original mortality rate without treatment is around: After dantrolene was introduced as a form of treatment the mortality rate dropped to Due to early detection methods mortality rate has decreased to British Malignant Hyperthermia Associationis one of the few official support for MH. Malignant Hyperthermia is an inherited disorder that was first described by Michael Denborough in 1960. It is inherited by an autosomal dominant pattern. What Does Malignant Hyperthermia Do? This disorder increases the metabolism of skeletal muscles and causes an abnormal amount of calcium to be present in those muscles, and usually appears after general anesthetics are applied and sometimes heat and exercise. If left untreated this can be fatal. Effects On The Body The increased metabolism ofskeletal muscles causes unprovoked muscle aches.Other symptoms include increased heart rate, andfever-like body temperatures.MH can also lead to heart,liver and kidney failure and the accumulation of fluids in lungs but these issues onlyarise if the subject is leftuntreated.Malignant hyperthermia is more common in males (2:1) due to them usually having a higher content than females. Age Of Onset The mean age of all cases is 19years old. But 52.1% of reactionsoccur to those who are 15 yearsold or younger. The oldest recorded subject to experiencethe reactions was 78 years old. Rate Of Occurance Mortality Rate, Treatment and Support Dantrolene is the main drug usedduring treatment and lowered themortality rate drastically. Monitoring the concentration of CO is a method of early detection of malignant hyperthermia that worksin tandem with dantrolene. Geneticmethods of early detection arevery inaccurate.
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