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Created with Fabric.js 1.4.5 Mercedes Vidal Period 7th December 11th, 2014 Common Dosage? Lanoxin/Digoxin Ischemia and numerous more... Decreased Cardiac Output in patients with Acute Myocardial Infarction in patients with preserved Left Ventricular Systolic Function Three routes of admission: Elixir Tablet Parenteral Warnings/Precautions Lanoxin causes an effect on the "Sodium pump" in cells to maintain the flow of ions. It then causesincreased and automaticity, stimulates the SA and AV Nodes, slows the heart rate, increase the force of contractions, and decreases the activation of the SNS. inotropy What is it? Special Populations Pediatric Patients RenalImpaired Geriatric Patients What are the routes of admission? Pregnant Women Nursing Mothers Loading in Adults and Pediatrics 10 years and Older There are two types of dosages: Although, the drug can be takenwithout the loading dosage. Loading and Maintenance 8-12 mcg/kg Initially administer half the loading dose, then 1/4 the loading dose every 6-8 hours twice. Ventricular Fibrilliation in patients with Accessory AV Pathway Sinus Bradycardia and Sino-atrial Block Digoxin Toxicity a complication of digitalis therapy, drugs are made from this type of plant 2.4-3.6 mcg/kg Maintenance in Adults and Pediatrics 10 years and Older Cost? Administer once daily. Lanoxin Tablet62.5 mcg - $2.59125 mcg - $0.72-$2.59$187.5 mcg - $2.59250 mcg - $1.58Digoxin Elixir50 mcg/mL - 60 mL $0.65Digoxin Tablet125 mcg - $0.34-$0.95250 mcg - $2.62 Hypersensitivity to Digoxin (rash, swelling of the mouth, lips or throat, or difficulty breathing)Ventricular Fibrillation Pharmacokinetics Mild/Moderate Heart Failure in AdultsHeart Failure in PediatricsAtrial Fibrillation in Adults Should be used in combination with a diuretic and ACE inhibitor. Indications/Usage Contraindications Absorbtion Distribution Excretion Metabolism Digoxin is concentrated in tissues and has a largevolume of distribution (475-500L). The drug crosses blood- brain barrier and placenta. Rate is slowed when taken after eating but the amount absorbed is unchanged. A meal with high bran will decrease the amount absorbed when taken orally. The amount eliminated is proportional to the total bodycontent. Digoxin has a half life of 1.5-2 days in normal patients. Only thirteen percent of administered Digoxin was metabolized in healthy patients. Clinical studies have shown that the adverse reactions of Lanoxin are dose-dependent!This means that the side effects are less common when the drug is used within the recommended dose range and when carefulattention is taken on the concurrent medications and conditions.
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