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Created with Fabric.js 1.4.5 Route Of Administration Common Dosage Maximum recommendeddaily oral dose =15 mg Patients with hemodialysis maximum daily dosage = 7.5 mg Indication Osteoarthritisknee and hip Rheumatoid Arthritissmall joints in your hands and feetJuvenile rheumatoid arthritis: persistent joint pain, swelling and stiffness in the joints Member of oxicam class; inhibits synthesis of prostaglandins in bodytissues by inhibiting at least 2 cyclo-oxygenase isoenzymes(COX), COX-1 and COX-2; COX-2 may be inhibited to a greater extent than COX-1. Mechanism of Action Osteoarthritis Rheumatoid Arthritis (Adult Patients)Juvenile Rheumatoid Arthritis (Pediatric patients) Absorption: Bioavailability: 89%Distribution:Protein bound: 99.4%Vd: 10 LMetabolism: In liver by CYP3A4Enzymes inhibited: COX-1, COX-2Elimination: Urine, feces Special Population Pharmacokinetics Walmart: $4.00Target: $4.00Kmart: $5.61Walgreens: $9.83CVS Pharmacy: $11.99 Cost May increase risk of: Cardiovascular, Gastrointestinal risk, Gastrointestinal ulcer, etcMay cause: severe skin reaction, dizzinessdecrease platelet adhesion and aggregation WARNING Cantraindications Absolute:Salicylate allergy and Perioperative pain Relative: Bleeding disorder, Gastritis,Late preganancy, etc Meloxicam Generic name: Mobic Oral osteoarthritis was evaluated in six double-blind (ranging 4weeks-6months)rheumatoid arthritis was evaluated in a 12-week, double-blind,controlled multinational trial Johnny Do Gonzalez P.5 Clinical Study
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