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Created with Fabric.js 1.4.5 Sickle India, CaribbeanIslands, CentralAmerica, and Saudi Arabia These countries are also affected by this diesease. Africans Hispanics MediterraneanCountries Canada 1 in 5oo people of African descent are affected 1 out of 36,000 Hispanics areAffected by thisdisease. Countries like Turkey, Greece, and Italy are affected. -Cell Disease Regular Blood Cell SickleBlood Cell Symptoms: Key Statistics: Affects about 3500 to4500 Canadians Fatigue Pale Skin RapidHeartRate Shortness of Breath Painful Joints HeartFailure Treatments: Inheritance: Gene Therapy Bone MarrowTransplant BloodTransfusions Comprehensive Care Surgery This disease has an autosomal recessive pattern (both copies of the mutated HBB hemoglobin gene are inherited), Although an individual who is heterozygous for the gene (has one normal gene and one mutated gene) often shows no symptoms, yet may have a combination of normal red blood cells and sickled red blood cells. Sickle-cell disease (SCD) is a genetic hereditary hemoglobin disease that affects the shape of red blood cells making them crescent, or sickle shaped, unlike normal, unaffected red blood cells which are shaped like circular discs. By: Juniette Centeno and Daravan Phimmanao Heterozygous Advantage: Individuals who are heterozygous for SCD have a heterozygous advantage over those who are homozygous for the abnormal gene and carry the sickle-cell trait contributing to being more resistant against malaria (transmitted by flies). (Data & Statistics. (n.d.). Retrieved March 8, 2015, from (Sickle Cell Disease, Sickle Cell Anaemia, Blood Cells | (n.d.). Retrieved March 7, 2015, from (Sickle Cell Disease, Sickle Cell Anaemia, Blood Cells | (n.d.). Retrieved March 7, 2015, from (Simple Facts about Sickle Cell. (n.d.). Retrieved March 7, 2015, from sickle-cell-disease/simple-facts-about-sickle-cell/) (Menu. (n.d.). Retrieved March 7, 2015, from (Mystery solved: How sickle hemoglobin protects against malaria. (n.d.). Retrieved March 7, 2015, from Hemoglobin molecule
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