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Created with Fabric.js 1.4.5 Heroin Heroin is a drug made from morphine which is found in poppy seeds. It is extremely dangerous and addictive. Approximately 1.6 percent of American adults have used heroin at least once What is it? Heroin: originally created in 1874 by adding two acetyl groups to a morphine molecule. intended as a treatment for opium addicts. 3-4 times stronger,more addictive. than opium What are the Effects? Heroin users usually experience a rush of euphoria followed by flushed skin, heavy arms and legs and clouded mind. This is followed by a period of drowsiness. And the Dangers? Heroin is one of the most dangerous drugsin existence. It is highly addictive, addictsneed more and more of the drug to produce the same effects. This leads in most cases to a fatal overdose.The effects of heroin dependence are extreemly dangerous andin most cases, Deadly. The average life expectancy for a Heroin addict is 18 years. How Does It Work? Heroin ligands have a shape similar to that of the natural opiates calledendorphins that occur naturally in our bodies, they release a chemical called dopamine which causes the happiness and painrelief associated with opioid use. The cell signalling pathway is the opioid system double click to changethis text! Drag a cornerto scale proportionally. Step 1: Heroin ligands bind to the opiate receptors and blocks the emission of GABAStep 2: The dopamine inhibitorGABA is blocked and dopamine is released into the synapseStep 3: Dopamine attaches to the Dopamine receptors causing the effects common with Heroin andother opiates. What is the ligand and typeof Receptor? The ligand active in the function of Heroin and other opiates is called the Opiate receptor. Withoutand opiate, a neurotranmitterthat block dopamine release calledGABA is active. Opiates like herion block this Neurotransmitter and causethe release of Dopamine What are the Basics of signal transduction? What are the specificsof cellular and organismalresponse? As dopamine is recived by dopaminereceptors, it causes blocks pain receptors and triggers a biocheical response, inducing happniess and relaxation, as well as the othereffects previously described What does the Signal pathway look like? Researchers are looking for newways to cure heroin and opioid dependence. By blocking the dopamine production, TLR4 sceintistshope to help heroin addcits overcome their addiction What is the current direction of research? Don't do Drugs!!!
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