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Created with Fabric.js 1.4.5 Production of Hepatitis B Vaccine From Yeast Fermentation Citation: Fieschko, John. "Fermentation methods for hepatitis vaccine production." WO 1987001129 A1. 1987. < of hepatitis B vaccine through fermentation&hl=en&sa=X&ei=UiSGUti6PIPi4APN-oGIDg&ved=0CDkQ6AEwAA> Biological Economic Cloned HBV DNA (DNA from Hepatitis B virus) Isolated HBsAg (Hepatitis B antigens) 1. Yeast is generally recognized as safe2. Yeast grows in cultures in large quantities3. The technology of yeast is well understood4. As eukaryotic cells, yeast contains the mechanisms for glycosylation, phosphorylation, and methylation5. Yeast cells tolorate the HBsAg protein well Cost of HBsAg polypeptides in yeast can be lowered in several ways.1. enhancing the growth of yeast2. enhancing the production of or preventing the destruction of HBsAg polypeptides once produced(Regulation of rate of fermentation is one way to control this) Yeast DNA Combination of yeast DNA and HBsAg Advantages of YEAST Growth and fermentationof yeast and HBsAg cells Chromatography columns are used to separate key proteins from batches of yeast cells Have epinephrine in case of adverse side effects. yeast DNA HBsAg DNA Vaccine to be administered intramuscularly NOT intravenously or intradermally Hepatitis B: causes a systematicinfection, with a major pathologyin the liver. Hepatitis B Vaccine Production Process Sharp, Merck, and Dohme Corp. United States. Food and Drug Administration. Recombivax HB. New Jersey: Merck Sharp & Dohme Corp., 1998. Print. <> Vaccine/General Information
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