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Created with Fabric.js 1.4.5 Common: 1 spray in each nostril daily (100 mcg/day).Daily maximum: 2 sprays in each nostril (200 mcg/day). average volume is 4.2 L/kghas rapid lipid solubility and tissue bindingabout 91% binds to human plasma proteins has been found to decrease nasal mucosal eosinophils and basophils in patients(precise mechanism not known) FLONASE low bioavailability throughintranasal route: averaging less than 2% Absorption Contraindications Clinical Studies Warnings/Precautions high blood clearance- average, 1,093 mL/min17β-carboxylic acid derivative of fluticasone propionate is the only circulation metabolite that has been detected Metabolism Excretion Special Populations Indications to treat allergic rhinitis symptoms; for the management of the nasal symptoms of seasonal and perennial allergic andnonallergic rhinitis in adults and pediatric patients 4 years of age and older. Replacing a systemic corticosteroid with a topical corticosteroid may cause patient to exhibit signs of adrenal insufficiency, and symptoms of withdrawal, such as joint and/or muscular pain, lassitude, and depression. The use of intranasal corticosteroids with otherinhaled corticosteroids could increase the risk of signs or symptoms of hypercorticism and/or suppression of the HPA axis. Distribution Fluticasone propionate nasal spray was not studied in any special populations, and no gender-specific pharmacokinetic data have been obtained. Cost Generic Brand $80-$100 Christine LamaieRocha Period 7 (fluticasone propionate) corticosteroid with anti-inflammatory activity Flonase has a terminalelimination half-life of approx. 7.8 hours Mechanism of Action Conditions: Increased Pressure in the Eye, Increased Pressure in Eyes, Cataracts, Operation onNose, Ulcer of the nasal septum, Herpes Simplex Infection of the Eye, Perforation of the nasal septum,Liver Problems, Nosebleed, Injury to the Nose, Active/Inactive Tuberculosis,Measles, untreated Infection caused by bacteria, untreated Infection caused by a fungus, decreasedFunction of the Adrenal gland.Allergies:CORTICOSTEROIDS (GLUCOCORTICOIDS) Pharmacokinetics $11-$20 In subjects treated with FLONASE Nasal Spray,a significantly greater decrease in total nasal symptom scores than vehicle placebo-treated patients. Also, areduction in Nasal mucosal basophils and eosinophils was found at the end of treatment.Two randomized, placebo-controlled 28-day trials were conducted in the U.S. on 732 patients (243 given FLONASE)12 years of age and older to investigate as-needed use of FLONASE Nasal Spray (200 mcg) inpatients with seasonal allergic rhinitis. The studiesdemonstrated significantly greater reduction in nasalcongestion, rhinorrhea, sneezing, and nasal itching compared to placebo. Dosage
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