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Created with Fabric.js 1.4.5 Genes are not all expressedat the same time. Rather, they can be turned off/on,differentially, throughout thelifespan. Methylation is an epigeneticmechanism that can regulategene expression. Methylation refers to the addition of a methyl (CH3) group to the cytosine or guanine nucleotides contained in DNA. Is epigenetics important? Is epigenetics important? The Epigenome: Differential Reproductive Strategies The Epigenome: Differential Reproductive Strategies What is epigenetics? What is epigenetics? Literally, above the genome! YES! YES! Why? Why? Epigenetics mechanisms are directly regulated by theenvironment. That is, the environment can regulategene expression. Researchers have found, in particular, early rearingenvironment(nurture) has aprofound effects on an organisms development. In particular, early maternal care, in rodents, has been shown to regulate the estrogen receptor gene. This gene is directly related to sexual development. The Model The Model The prediction: Maternal investment, nurturing, impacts reproductive successthrough regulating the Estrogen Receptor. The prediction: Maternal investment, nurturing, impacts reproductive successthrough regulating the Estrogen Receptor. Estrogen levels predictfertility in both rodents and humans. Estrogen levels predictfertility in both rodents and humans. What are we to make of this? What are we to make of this? Darwin(1871) says, "...the very poor and reckless, who are often degraded by vice,almost invariably marry early...Those who marry early produce...many more children. Thus the reckless, degraded, and often vicious members of society, tend to increase at a quicker rate than the provident and generally virtuous members"(p.876) Darwin(1871) says, "...the very poor and reckless, who are often degraded by vice,almost invariably marry early...Those who marry early produce...many more children. Thus the reckless, degraded, and often vicious members of society, tend to increase at a quicker rate than the provident and generally virtuous members"(p.876) Onset of Puberty (www.irunfar.com) (www.news-medical.net) (Carey, 2012) (Francis, 2011) (blogs.psychcentral.com) (Carey, 2012) (Holmes et al., 2005) (Cameron et al., 2008) (Cameron et al., 2008) (Cameron et al., 2008) (Cameron et al., 2008) (Cameron et al., 2008) (http://2.bp.blogspot.com) (Darwin, 2006) (Cameron et al., 2008)
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