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Created with Fabric.js 1.4.5 Amy Nguyen-PhamGonzalez, 1st Elavil Amitriptyline Elavil- Amitriptyline Inhibits re-uptake of neurotransmitters: Serotonin and norepinephrine. Absorbed from GI tractWidely distributed in the bodyMetabolized in liverMostly excreted in urine. Small amount found in feces. How does Amitriptyline work? Special Populations Elderly--Increased risk of toxicity Clinical Trials Tests effectiveness of Amitriptyline in treating different conditions Comparing Amitriptyline to other drugs to determinewhich is more effective Increased risk of harm in hypersensitive pts.Should not be used with other serotonin and norepinephrine reuptake inhibitors.Not recommended for use after myocardial infarction. Antidepressant MigrainePainPost traumatic stress disorder Affordable. Price depends on:Amount of tablets&Dosage form Increased risk of suicidal thinking/action in <24 yrs old As an Antidepressant Adults: 25-150 mg/dayGeriatric: 10 mg(3 times/day)&20mg @ bedtimePediatric: (9-12 yrs) 1-5mg/kg/day (12-18 yrs) 20-200mg/day Switch to Amitriptyline:Allow 14 days to passafter discontinuing use of former inhibitor. Warnings Not recommended for use in <12 yrs old Not FDA approved for treatment of bipolar depression.Use during pregnancy can resultin deformities & delay in developmentfor baby. May worsen symptom(s) in schizophrenic patients,depressed patients. Amitriptyline may be reduced Precautions Potentially suicidal pts=No access to large amount Use with caution in ptsw/ impaired liver
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