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Created with Fabric.js 1.4.5 Concerta (aka Ritalin) - Methylphenidate Concerta- Initial, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day Consistent across ethnic groups; Agitation Plasma methylphenidate > of age resulted in increased apparent methylphenidate in adults and adolescents following oral administration was approximately 3.5 h. Methylphenidate is metabolized primarily by de-esterification to α-phenyl-piperidine acetic acid (PPA), the main urinary metabolite, accounting for approximately 80%. mean dose: men- 36.7 ngh/mL Hypersensitvity to Methylphenidate Glaucoma Tics Monoamine Oxidase Inhibitors The half-life of Attention Deficit Hyperactivity Disorder (ADHD) $60 - $90 Cost: Absorption Metabolism and Excretion Distribution Pharmacokinetics: Special Populations: Gender: Race: Age: women-37.1 ngh/mL in (adjusted AUC (0-inf)) however, the sample size may have been insufficient to detect ethnic variations. oral clearancehigher body weight lower exposures of total methylphenidate. concentrations increase rapidly maximum at about 1 hour,gradual Contraindication: Warning and Precautions Indications and usages Serious Cardiovascular EventsHypertension, Seizures ,Pre-Existing PsychosisVisual Disturbance ,Potential for Gastrointestinal Obstruction, Hematologic Monitoring Carcinogenesis, Mutagenesis,and Impairment of Fertility block the reuptake ofnorepinephrine and dopamineinto the presynaptic neuron and increase the release of these monoamines into theextraneuronal space Taken Orally Mechanism of action Dosage Kia Thomas Clinical Studies Ages 13-18:ADHD Rating Scale on mean score showed was significantly superior to placebo. Ages 6-12: studies on symptoms of ADHD were conducted by community schoolteachers using the Inattention / Overactivity with Aggression (IOWA) Conners scale
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