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Created with Fabric.js 1.4.5 VYVANSE Contraindications hypersensitivity to amphetamine products high potential for abuseor dependence Cost Stevens-Johnson Syndrome cardiomyopathy Pediatrics and Adults angioedema monoamine oxidase inhibitors $260 for a 30 day period Common dosage What's it for? Vyvanse is a sympathomimatic anime that promotes the release of dopamine and norepinephrine from presynaptic nerve terminals. Mechanism of Action Population structural cardiac abnormalities recurrent thoughts of death& suicide Doubleblind, randomized, placebocontrolled, parallelgroup study was conducted in children ages 6 to 12 years.Patients were randomized to receive final doses of 30 mg, 50 mg, or 70 mg of Vyvanse or placebo once daily in the morning. The primary efficacy outcome was change in Total Score from baseline to endpoint in investigator ratings on the ADHD Rating Scale , an 18item questionnaire with a score range of 054 points that measures the core symptoms of ADHD which includes both hyperactiveimpulsive and inattentive subscales. The highest dosage was numerically superior with all yielding results. Double-blind, randomized, placebo-controlled, parallel-group study was conducted in children ages 6 to 12 years.Patients were randomized to receive final doses of 30 mg, 50 mg, or 70 mg of Vyvanse or placebo once daily in the morning. The primary efficacy outcome was change in Total Score from baseline to endpoint in investigator ratings on the ADHD Rating Scale , an 18-item questionnaire with a score range of 0-54 points that measures the core symptoms of ADHD which includes both hyperactive/impulsive and inattentive subscales. The highest dosage was numerically superior with all yielding results. lisdexamfetamine dimesylate Vyvanse is indicated for the treatment of ADHD. urticaria Warnings structural cardiac abnormalities coronary artery disease Peak plasma time for lisdexamfetamine is 1 hourand 3 1/2 hours fordextroamphetamine. myocardial infarction stroke sudden death Clinical Trials 30 mg is the recommended startingdosage with 10 mg or 20 mg adjustments as needed weekly.Dosage not to exceed 70 mg. Absorption Metabolism After being taken orally, Lisdexamfetamine is quickly absorbed through the gastrointestinal tract. Lisdexamfetamine converts into dextroamphetamine and l-lysine primarily in blood due to the hydrolytic activity of red blood cells.
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