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Created with Fabric.js 1.4.5 Pro Air Albuterol Sulfate Metabolism Clinical Studies 4 yrs < In clinical studies for athletes, pediatric pts, adults, The primary enzyme responsible for Life-threatening paradoxical bronchospasm may occur Oral Inhalation Albuterol relaxes smooth muscle airways $54 1 inhaler with 8.5 g of 90 mcg. Young and athletic, old and decrepit, HFA does not discriminate Not a substitute for corticosteroids one inhalation every 4 hours suffices 2 inhalations 15 to 30 minutes pre-exercise Shown in controlled clinical trials to have more effect on respiratory tract in form of bronchial smooth muscle relaxation Than isopretanol For use of asthma/bronchospasm ProAir HFA proved to be more effective than the leading placebo Excretion Cardiovascular effects may occur Hypokalemia and changes in blood glucose may occur of either the parent compound or the primary metabolite. metabolism of albuterol is SULTIA3 (sulfotransferase). The primary route of eliminationl is through renal excretion (80% to 100%) Less than 20% of the drug is detected in the feces Special Populations There are no clinical trials on pregnant women, the elderly neonates renal or hepatic impairment Proair HFA. (n.d.). Retrieved December 11, 2014, from PROAIR HFA (albuterol sulfate) INHALATION AEROSOL. (2008, January 1). Retrieved December 11, 2014, from beta2-adrenergic agonist.
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