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Created with Fabric.js 1.4.5 No Drug Usage Heroin Abuse Normal functioning cell signal transduction pathways have three stages with reception, transduction and response. Reception is whenthe ligand attaches to the receptor. Transduction is when the signal is converted to bring about a cellular response. Response is the cellular response to the ligand (Campbell and Reece 206-25). Heroin, after converting to morphine, is the ligand and attaches to the G-protein receptor in the VTA. It is mimicking endorphins, which the bodynaturally uses as neurotransmitters("The Mechanism of Action of Heroin at the Mu (m) Opiate Receptors"). Reception Transduction Response The receptor inhibitsGABA. GABA's usualjob is to reduce the amount of dopaminereleased (calming nervousactivity). Its job thus cannot be fulfilled("GABA";"The Mechanism of Action of Heroin at the Mu(m) Opiate Receptors). The dopamine output is increased and thus createsan increase in thefeeling of pleasurethat comes from theeuphoric effect ("Opiate Receptors and Actions"). Heroin Heroin Usage G-Protein Coupled Receptor Normal Functioning G-Protein Coupled Receptor Heroin is an opiate. This means that it comes from the seed of a poppy plant. When injected,it rushes through the bloodstream to the brain and createsan abnormal high, euphoriceffect (DiConsiglio). Heroin Take Over Grace Torres and Abbey Rosenquist
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