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Created with Fabric.js 1.4.5 AFREZZA Want a New Type of Cure for Diabetes? Types of Diabetes Type 1:Immune system destroys insulin produced by pancreas.Type 2: Body cannot properly use or make enough insulin it makes.Gestational: Inadequate levels of insulin production caused by pregnancy harmones. Usually occurs during Type 2 diabetes (Andrew,2014). What Is It? 1980 Afrezza is a recent form of human insulin that can be inhaled,which was created by Dr. Robert J. Smith from the Mannkind Company. It consists of Technosphere Insulin (TI) combined with inhalation powder, as well as a breath activated inhaler. This device is used 1 min before eating and treats type 1 and 2 diabetics (Rotenstein, 2012). Benefits History 1990 - Problems getting Afrezza approved by FDA.-March 2009: Filed report of approval to FDA, which got rejected due to its risks of having lung cancer. FDA told Mannkind to do more clinical tests in 2011 (Rotenstein, 2012). Risks 2014 What is Diabetes? Diabetes is a disorder of the pancreas that prevents insulin production. This affects the body's ability to effectively use and regulate sugars. The lack of production of harmone insulin increases the amount of blood in the blood stream. Dr. Robert J. Smith wanted to create new insulin faster and easier to use than injected insulin. Led to first inhaled insulin "Exubera,"(2014). double click to change this header text! double click to change this header text! double click to change this header text! double click to change this title text! double click to changethis text! Drag a cornerto scale proportionally. double click to changethis text! Drag a cornerto scale proportionally. double click to change this header text! double click to changethis text! Drag a cornerto scale proportionally. Insulin pumps for Mini Med company created by Alfred E-Mann (2014). double click to changethis text! Drag a cornerto scale proportionally. 1921 Human Insulin (injected insulin) founded by Charles Best and Banting (Kling, 2014). 1) Decreases risk of having hypoglycemia.2) Faster action peaks after inhalation than injected insulin and rapid action analogs (12-15 mins).3) Lower risk of weight gain and lower fasting glucose levels (Paul, 2014). 1) Lung cancer.2) Bronchospasm.3) Coughing. Cost and availability are undefined because Afrezza is in its late stages of clinical testing and is in the process of being marketed. Challenges double click to change this header text! double click to change this header text! double click to change this header text! Next Steps double click to changethis text! Drag a cornerto scale proportionally. -Create a dramatic change in insulin therapy.-Dominate existing injected insulin and demolish other forms of treatment. for diabetes.-Advertise and market product.- Make Afrezza new type of insulin therapy. Glossary of New Terms - Hypoglycemia: Condition characterized by abnormally low levels of glucose in the bloodstream.-Bronchospasm: Spasm of bronchial smooth muscle causing bronchi to decrease in diameter.- Rapid action analogs:A type of insulin that is chemicallymodified to act faster than natural human insulin. Exubera had lack of acceptance from many patients due to it's bullky and heavy size. Mannkind continued to produce other inhaled insulin such as Afrezza (2014).
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