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Created with Fabric.js 1.4.5 Cystic Fibrosis (CF) Cystic Fibrosis is caused by a mutation in the CFTR gene. The mutation is inherited from the parents. CF is a lifethreatening disorder that damages lungs, digestivesystem and pancreas. CF affects the cells that producemucus, sweat and digestive enzymes. The defectivegene, CFTR, causes the secretion from the cells tobecome thick and sticky. Going against the usual function of the acting as a lubricant, these secretionsplug up they tubes, ducts, and passageways. CFTRCFTR, cystic fibrosis transmembrane conductance regulator, is a gene that codes for a protein conducting chloride ion channels.This gene controls the movement of salt and water in and out ofcells. The mutation of this gene affects chloride ion channel functionleading to dysregulation of epithelial fluid transport in the lung,pancreas and other organs. This dysregulation is the cause of cystic fibrosis. SymptomsCystic fibrosis effects the respiratory and the digestive systems.Some of the symptoms that appear when having cystic fibrosis arerepeated lung infections, breathlessness, wheezing, persistentcoughs that bring up thick mucus and stuffy nose. These symptomsoccur in the respiratory system. Other symptoms occur in the digestivesystems are poor weight gain/growth, intestinal blockage, severeconstipation and foul-smelling stool. Sources:"Cystic Fibrosis." Genetic Home Reference. Http://, 27 Jan. 2015. Web. 27 Jan. 2015."Cystic Fibrosis." Symptoms. Mayoclinic, Jan. 2015. Web. 30 Jan. 2015.Pics: Chloride ionChloride ions are important to the body because they help with the production of thin, freely flowing mucus which iscontrolled by the movement of water in tissues. Mucus is important for the body because it protects and lubricatesthe airways,digestive system and other organs. CF causes the mucus to become thick which causes clogs the airways and infections which leads to bacterial diseases in the lungs.
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