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Created with Fabric.js 1.4.5 Generic: Lidocaine PatchTrade: Lidoderm Up to 3 patches per 24 hours.Do not wear a patch for >12 hours. Metabolized by the liver to form the metabolitesmonoethylglycinexylidide (MEGX) and glycinexylidide (GX). Absorption -volume of distribution is 0.7 to 2.7 L/kg -60-80% bound to plasma proteins-crosses the blood brain and placental barriers -less than 10% is excreted unchanged-half life: parent drug 2.5-8 hours MEGX 2 hours GX 10 hours (metabolites) 3 ± 2% Cost Indications/Usage Clinical Studies Excretion Distribution -PregnancyCategory B-Teratogenic-Crosses into breast milk Special Populations Single-Dose vs. Vehicle Patch-35 pts. with post-herpetic neuralgia-Lidoderm performed statistically betterthan vehicle patch from 4 to 12 hours inregards to pain intensityMultiple-Dose vs. Vehicle Patch-32 pts. for 2 weeks-statistically significant differences favoredLidoderm in terms of: time to exit from the trial(14 days vs. 3.8 days), average daily pain relief and preference of treatment of the patients Cutaneous For relief of pain resulting from post-herpetic neuralgia.Only apply to intact skin. Common Dosage Metabolism Pharmacokinetics History of sensitivity to amide-type local anesthetics or to any other component ofLidoderm. -keep away from small children and pets-do apply more than recommended-do not apply to non-intact skin or eyes-use caution if allergic to para-aminobenzoicacid derivatives or have hepatic disease-caution when using along with antiarrhythmicdrugs and/or other local anesthetics-skin may show signs of irritation afterapplication; see physician if severe Warnings/Precautions Contraindications Karla Estrada, Pharmacology, Mrs. Gonzales, Period 5, 12/9/14 $338.48 Mechanism of Action 60 Patches
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